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Publications

We encourage our scientists and collaborators to share their research findings through publications in scientific journals and by giving presentations at scientific meetings. Below is a list of publications authored by our scientists and collaborators.

G-CSF Analog Publications

PEGylated G-CSF (BBT-015), GM-CSF (BBT- 007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the hematopoietic syndrome of the acute radiation syndrome.

Plett PA, Chua HL, Sampson CH, Katz BP, Fam CM, Anderson LA, Cox GN, Orschell CM
Health Physics Journal 106: 7-20, 2014.

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Site-specific protein PEGylation: application to cysteine analogs of recombinant human granulocyte colony-stimulating factor.

Rosendahl MS, Doherty DH, Smith DJ, Bendele AM, Cox GN.
BioProcess International 3 (4): 52-62, 2005.

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Enhanced circulating half-life and hematopoietic properties of a human granulocyte colony-stimulating factor/immunoglobulin fusion protein.

Cox GN, Smith DJ, Carlson SJ, Bendele AM, Chlipala EM, Doherty DH.
Experimental Hematology 32: 441-449, 2004.

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Hematopoietic properties of granulocyte colony-stimulating actor / immunoglobulin fusion proteins (G-CSF/IgG-Fc) in normal and neutropenic rodents.

Cox, GN, Chlipala EA, Smith DJ, Carlson SJ, Bell SJ, Doherty DH.
PLOS ONE Mar 17;9(3):e91990. doi: 10.1371/journal.pone.0091990, 2014.

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GM-CSF Analog Publications


 

Site-specific PEGylation of engineered cysteine analogues of recombinant human granulocyte-macrophage colony-stimulating factor.

Doherty DH, Rosendahl MS, Smith DJ, Hughes JM, Chlipala EA, Cox GN.
Bioconjugate Chemistry 16: 1291-1298, 2005.

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PEGylated G-CSF (BBT-015), GM-CSF (BBT- 007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the hematopoietic syndrome of the acute radiation syndrome.

Plett PA, Chua HL, Sampson CH, Katz BP, Fam CM, Anderson LA, Cox GN, Orschell CM.
Health Physics Journal 106: 7-20, 2014.

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Cytokine refacing effect reduces granulocyte-macrophage colony-stimulating factor susceptibility to antibody neutralization.

Heinzelman P, Carlson SJ, Cox GN.
Protein Engineering Design and Selection 28: 461-466, 2015.

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Interleukin-11 Analog Publications

 

Interleukin-11 protects against renal ischemia and reperfusion injury.

Lee HT, Park SW, Kim M, Ham A, Kim JY, Anderson LJ, Brown KM, D’Agati VD, Cox GN.
American Journal of Physiology - Renal Physiology 303: F1216-1224, 2012.

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PEGylated G-CSF (BBT-015), GM-CSF (BBT- 007), and IL-11 (BBT-059) analogs enhance survival and hematopoietic cell recovery in a mouse model of the hematopoietic syndrome of the acute radiation syndrome.

Plett PA, Chua HL, Sampson CH, Katz BP, Fam CM, Anderson LA, Cox GN, Orschell CM.
Health Physics Journal 106: 7-20, 2014.

Read more

 

 

Growth Hormone Analog Publications

 

A long-acting, monoPEGylated human growth hormone analog is a potent stimulator of weight gain and bone growth in hypophysectomized rats.

Cox GN, Rosendahl MS, Chlipala EA, Smith DJ, Carlson SJ, Doherty DH.
Endocrinology 148: 1590-1597, 2007.

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Beta Interferon Analog Publications

 

Site-specific PEGylation enhances the pharmacokinetic properties and anti-tumor activity of Interferon Beta-1b.

Lee JI, Eisenberg SP, Rosendahl MS, Chlipala EA, Brown JD, Doherty DH, Cox GN.
Journal of Interferon and Cytokine Research 33: 769-777, 2013.

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Alpha Interferon Analog Publications

 

Enhanced circulating half-life and anti-tumor activity of a site-specific pegylated interferon- a protein therapeutic.

Bell SJ, Fam CM, Chlipala EA, Carlson SJ, Lee JI, Rosendahl MS, Doherty DH, Cox GN.
Bioconjugate Chemistry 19: 299-305, 2008.

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A long-acting, highly potent interferon α-2 conjugate created using site-specific PEGylation.

Rosendahl MS, Doherty DH, Smith DJ, Carlson SJ, Chlipala EA, Cox GN.
Bioconjugate Chemistry 16: 200-207, 2005.

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Gamma Interferon Analog Publications

 

PEGylation improves the pharmacokinetic properties and ability of interferon gamma to inhibit growth of a human tumor xenograft in athymic mice.

Fam CM, Eisenberg SP, Carlson SJ, Chlipala EA, Cox GN, Rosendahl MS.
Journal of Interferon and Cytokine Research 34: 759- 768, 2014.

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Erythropoietin Analog Publications

 

Design of homogeneous, monoPEGylated erythropoietin analogs with preserved in vitro bioactivity.

Long DL, Doherty DH, Eisenberg SP, Smith DJ, Rosendahl MS, Christensen KR, Edwards DP, Chlipala EA, Cox GN.
Experimental Hematology 34: 697-704, 2006.

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